- The Biohacker's Protocol
- Posts
- Every Supplement.
Every Supplement.
- Their Benefits and Side Effects
Table of Contents
Vitamins
Names | Benefits | Side Effects |
---|---|---|
Vitamin A | Supports vision, skin health, and immune function; crucial for growth and development. | High doses can cause nausea, dizziness, liver damage, and birth defects if taken during pregnancy. |
Vitamin B1 (Thiamine) | Aids energy production; supports nerve, muscle, and heart health. | Rare; possible allergic reactions and stomach upset in high doses. |
Vitamin B2 (Riboflavin) | Converts food into energy; supports skin and eye health; acts as an antioxidant. | Bright yellow urine; possible nausea at high doses. |
Vitamin B3 (Niacin) | Supports metabolism and heart health; aids in DNA repair. | High doses may cause skin flushing, nausea, and liver toxicity. |
Vitamin B5 (Pantothenic Acid) | Metabolizes fats, proteins, and carbs; essential for hormone production | Excessive intake can lead to diarrhea and digestive issues |
Vitamin B6 (Pyridoxine) | Supports brain health and red blood cell formation; regulates mood | High doses can cause nerve damage, sensitivity to sunlight, and numbness |
Vitamin B7 (Biotin) | Promotes healthy skin, hair, and nails; supports energy metabolism | Generally safe; high doses may interfere with lab tests |
Vitamin B9 (Folate/Folic Acid) | Crucial for DNA synthesis and cell growth; supports red blood cell production | Excessive intake can mask vitamin B12 deficiency and cause digestive issues |
Vitamin B12 (Cobalamin) | Boosts energy, supports nerve function, and aids red blood cell production | Generally safe; high doses may cause mild skin rashes |
Vitamin C (Ascorbic Acid) | Boosts immune health, acts as an antioxidant, and promotes collagen production | High doses can cause stomach upset, diarrhea, and kidney stones |
Vitamin D | Promotes calcium absorption; supports bone health and immune function | Excessive intake may lead to nausea, kidney stones, and heart damage |
Vitamin E | Acts as an antioxidant; supports immune function; maintains healthy skin | High doses can cause nausea, stomach cramps, and increase bleeding risk |
Vitamin K | Essential for blood clotting and bone health | Generally safe; can interact with blood-thinning medications, affecting their efficacy |
Minerals
Names | Benefits | Side Effects |
---|---|---|
Calcium | Essential for strong bones and teeth, supports nerve signaling, muscle contraction, and blood clotting. | Excess intake can cause kidney stones, constipation, and may interfere with the absorption of other minerals like zinc and iron. |
Iron | Crucial for forming hemoglobin in red blood cells, supports oxygen transport, and boosts energy and immune function. | High doses can lead to stomach upset, constipation, nausea, and, in severe cases, organ damage due to iron toxicity. |
Magnesium | Supports muscle and nerve function, regulates blood sugar and blood pressure, and aids in energy production. | High doses can cause diarrhea, stomach cramps, nausea, and in extreme cases, heart issues or low blood pressure. |
Zinc | Boosts the immune system, supports wound healing, DNA synthesis, and cell division. | Excess intake may cause nausea, vomiting, loss of appetite, stomach cramps, headaches, and reduced immune function |
Selenium | Acts as an antioxidant, supports thyroid health, and may protect against cell damage | High doses can lead to selenosis, resulting in hair loss, nail brittleness, garlic breath odor, and, in severe cases, neurological abnormalities. |
Copper | Essential for iron metabolism, energy production, and the formation of red blood cells and connective tissues | Excessive intake can cause nausea, vomiting, abdominal pain, and may lead to liver and kidney damage over time |
Manganese | Involved in bone formation, blood clotting, and metabolism of amino acids, cholesterol, and carbohydrates | High levels can cause neurological issues, similar to Parkinson's disease, especially in individuals with existing liver problems |
Chromium | Enhances the action of insulin, supports blood sugar control, and may aid in weight management | High doses can cause stomach irritation, low blood sugar, and in some cases, kidney or liver damage |
Molybdenum | Helps in processing proteins and genetic material, supports enzyme function in detoxification. | Excessive intake can lead to gout-like symptoms, joint pain, and high levels of uric acid |
Iodine | Essential for thyroid function and the production of thyroid hormones, which regulate metabolism | High intake may lead to thyroid dysfunction, causing hyperthyroidism or hypothyroidism, and may result in thyroid gland inflammation |
Potassium | Helps maintain fluid balance, supports muscle contractions, and regulates blood pressure | Excessive intake can lead to hyperkalemia, causing muscle weakness, irregular heartbeat, and in extreme cases, cardiac arrest |
Sodium | Regulates fluid balance, supports nerve and muscle function, and helps maintain blood pressure | High intake can lead to high blood pressure, increased risk of heart disease, stroke, and water retention |
Phosphorus | Important for healthy bones and teeth, helps in energy production and storage, and maintains acid-base balance | High levels can cause an imbalance with calcium, leading to weakened bones, and may result in kidney damage over time |
Silicon (Silica) | Supports bone health, skin elasticity, hair, and nail strength; may aid in collagen formation | High doses can lead to kidney issues, though side effects are generally rare with dietary intake |
Boron | Supports bone health, metabolism of magnesium and phosphorus, and may influence hormone levels | Excess intake can cause nausea, vomiting, diarrhea, and in extreme cases, hormonal imbalances |
Amino Acids
Name | Benefit | Side Effects |
---|---|---|
L-Glutamine | Supports muscle recovery, boosts immune function, promotes gut health by maintaining the integrity of the intestinal lining | Generally safe; high doses may cause stomach upset, bloating, and in rare cases, an increased risk of seizures in individuals with certain health conditions. |
L-Arginine | Improves blood flow, supports cardiovascular health, aids in wound healing, and may enhance exercise performance by increasing nitric oxide production. | High doses can cause gastrointestinal discomfort, diarrhea, bloating, low blood pressure, and may exacerbate asthma symptoms. |
L-Carnitine | Supports energy production by transporting fatty acids into the mitochondria, enhances exercise performance, and may aid in weight management and heart health. | High doses can lead to nausea, stomach cramps, diarrhea, and a "fishy" body odor |
L-Theanine | Promotes relaxation without drowsiness, improves focus, and may reduce anxiety and stress by increasing GABA and dopamine levels in the brain | Generally safe with few reported side effects; excessive intake may cause headaches, dizziness, or gastrointestinal issues |
BCAAs: (Leucine, Isoleucine, Valine) | Supports muscle protein synthesis, reduces exercise-induced muscle soreness, and may enhance exercise performance and recovery. | High doses can lead to gastrointestinal discomfort, nausea, headaches, and may interfere with blood sugar regulation if taken excessively. |
L-Lysine | Supports immune function, helps in collagen formation, promotes wound healing, and may reduce anxiety by influencing serotonin receptors. | High doses may cause stomach pain, diarrhea, and potential gallstone formation with long-term excessive intake |
L-Tyrosine | Supports the production of neurotransmitters (dopamine, adrenaline), enhances mental performance, particularly during stress, and may help improve mood | High doses can cause headaches, nausea, heartburn, and an increase in thyroid hormone levels, leading to potential thyroid dysfunction |
Taurine | Supports cardiovascular health, muscle function, and central nervous system development; acts as an antioxidant and may improve exercise performance | Generally considered safe; high doses may lead to stomach pain, nausea, and in rare cases, electrolyte imbalances |
L-Citrulline | Improves blood flow, enhances exercise performance, reduces muscle fatigue, and may support cardiovascular health by increasing nitric oxide production | Generally well-tolerated; high doses may cause stomach discomfort, bloating, and diarrhea |
L-Ornithine | May reduce fatigue, enhance athletic performance, and support liver function by aiding in the detoxification process | High doses can lead to gastrointestinal issues such as nausea, diarrhea, and stomach cramps |
N-Acetylcysteine (NAC) | Acts as an antioxidant, supports detoxification by replenishing glutathione, and may improve respiratory health and immune function | Can cause nausea, diarrhea, stomach pain, and in rare cases, an allergic reaction (rash or difficulty breathing) |
Beta-Alanine | Increases muscle carnosine levels, reduces muscle fatigue, and enhances exercise performance, particularly in high-intensity activities | High doses can cause a tingling sensation on the skin (paresthesia), which is harmless but can be uncomfortable |
L-Tryptophan | Precursor to serotonin, supports mood regulation, sleep quality, and may alleviate symptoms of depression and anxiety | Can cause nausea, drowsiness, headaches, and in excessive amounts, may lead to serotonin syndrome, especially if combined with certain medications |
Herbal and Botanical Supplements
Names | Benefit | Side Effects |
---|---|---|
Ashwagandha | Reduces stress, supports cognitive function, improves mood, boosts energy, enhances overall vitality. | High doses can cause stomach upset, diarrhea, and drowsiness. |
Ginseng (Panax, Siberian, American) | Boosts energy, improves cognitive function, reduces inflammation, supports immune health. | May cause insomnia, headaches, digestive issues, and elevated blood pressure in high doses. |
Turmeric/Curcumin | Reduces inflammation, supports joint health, acts as an antioxidant, promotes heart health. | High doses may cause stomach upset, nausea, and dizziness. |
Ginger | Aids digestion, reduces nausea, alleviates menstrual pain, has anti-inflammatory properties. | High doses can cause heartburn, stomach upset, and increase the risk of bleeding. |
Echinacea | Boosts immune system, reduces symptoms of colds and respiratory infections, supports overall immune health. | Can cause nausea, stomach pain, and allergic reactions, especially in those allergic to ragweed. |
Garlic | Supports heart health, reduces blood pressure, has antimicrobial and immune-boosting properties. | May cause bad breath, body odor, stomach upset, and increased risk of bleeding. |
Ginkgo Biloba | Improves circulation, enhances cognitive function, may alleviate anxiety symptoms. | May cause headaches, dizziness, stomach upset, and increased bleeding risk. |
St. John’s Wort | Supports mood regulation, may reduce symptoms of depression and anxiety, promotes emotional well-being. | Can interact with various medications, causing side effects like dizziness, dry mouth, and light sensitivity. |
Saw Palmetto | Supports prostate health, reduces symptoms of benign prostatic hyperplasia (BPH), and promotes urinary health | May cause mild stomach upset, headache, and dizziness |
Milk Thistle | Supports liver health, promotes detoxification, has antioxidant properties | Generally well-tolerated; high doses may cause stomach upset and diarrhea. |
Rhodiola Rosea | Reduces fatigue, boosts mental performance, alleviates symptoms of stress, and enhances mood. | May cause dizziness, dry mouth, and sleep disturbances. |
Valerian Root | Promotes relaxation, improves sleep quality, reduces symptoms of anxiety. | May cause dizziness, headaches, stomach upset, and morning grogginess if taken in high doses. |
5. Essential Fatty Acids
Names | Benefit | Side Effects |
---|---|---|
Omega-3 (EPA, DHA) | Supports heart health, reduces inflammation, improves brain function, supports eye health, and may reduce symptoms of depression. | High doses can cause fishy aftertaste, bad breath, indigestion, nausea, diarrhea, and may increase the risk of bleeding. |
Omega-6 (Linoleic Acid) | Promotes skin and hair health, supports bone health, regulates metabolism, and maintains reproductive health. | Excessive intake may lead to inflammation, increase the risk of heart disease, and may upset the balance between omega-6 and omega-3 in the body. |
Omega-9 (Oleic Acid) | Supports heart health by improving cholesterol levels, reduces inflammation, and may aid in blood sugar control. | Generally safe with few side effects; excessive intake may lead to unwanted weight gain due to high calorie content. |
Flaxseed Oil | Rich in alpha-linolenic acid (ALA), supports heart health, reduces inflammation, promotes skin health, and may help regulate digestion. | High doses can cause diarrhea, bloating, gas, and may interfere with blood clotting. |
Krill Oil | Provides a more easily absorbed form of omega-3 (EPA, DHA), supports heart health, reduces inflammation, and may improve joint health. | May cause stomach upset, fishy burps, and an increased risk of bleeding, particularly when taken with blood-thinning medications. |
Probiotics & Prebiotics
Names | Benefit | Side Effect |
---|---|---|
Lactobacillus (e.g., Lactobacillus acidophilus) | Supports gut health, helps restore the natural balance of gut bacteria, improves digestion, boosts immune function, and may reduce symptoms of irritable bowel syndrome (IBS). | May cause mild digestive issues such as gas, bloating, and diarrhea, particularly when first starting supplementation. |
Bifidobacterium (e.g., Bifidobacterium lactis) | Aids in digestion, supports immune health, helps alleviate constipation, and may reduce the symptoms of IBS. | Possible gas, bloating, and stomach discomfort during initial use; typically well-tolerated in the long term. |
Saccharomyces Boulardii | Supports gut health, helps prevent and manage diarrhea (including antibiotic-associated diarrhea), may alleviate symptoms of inflammatory bowel diseases. | May cause mild digestive issues such as gas, bloating, and thirst; rare cases of fungemia in immunocompromised individuals |
Inulin | Promotes the growth of beneficial gut bacteria, supports digestion, improves bowel regularity, and may help regulate blood sugar levels. | Can cause gas, bloating, and stomach discomfort, particularly when taken in large amounts or by individuals with sensitive digestive systems. |
Fructooligosaccharides (FOS) | Supports the growth of beneficial gut bacteria, improves digestion, may enhance mineral absorption, and supports bowel regularity. | High doses may cause gas, bloating, and stomach discomfort, especially in those with sensitive digestive systems or irritable bowel syndrome (IBS) |
Antioxidants
Names | Benefit | Side Effects |
---|---|---|
Coenzyme Q10 (CoQ10) | Supports energy production in cells, acts as an antioxidant to protect cells from oxidative damage, supports heart health, and may improve exercise performance. | May cause mild digestive issues such as nausea, diarrhea, stomach upset, and, in some cases, insomnia when taken in high doses. |
Glutathione | Acts as a powerful antioxidant, supports detoxification, boosts the immune system, and may improve skin health and appearance. | Generally well-tolerated; high doses may lead to bloating, cramping, and allergic reactions (rash, itching) in sensitive individuals. |
Alpha-Lipoic Acid (ALA) | Supports energy metabolism, reduces inflammation, improves nerve function, and may help regulate blood sugar levels. | May cause mild side effects like nausea, rash, and stomach upset; high doses can lead to a drop in blood sugar levels, especially in people on diabetes medication. |
Resveratrol | Acts as an antioxidant, supports heart health, has anti-inflammatory properties, and may protect against cell damage and aging | High doses can cause digestive issues like diarrhea, stomach upset, and may interact with blood-thinning medications, increasing bleeding risk. |
Astaxanthin | Powerful antioxidant that protects cells from oxidative stress, supports skin health, reduces inflammation, and may enhance eye and heart health. | Generally well-tolerated; in rare cases, high doses may lead to changes in skin color (slight orange tint), stomach pain, or hormonal imbalances |
Quercetin | Acts as an anti-inflammatory and antioxidant, supports immune function, and may help alleviate allergy symptoms | High doses may cause headaches, stomach upset, and tingling sensations in arms and legs |
N-Acetylcysteine (NAC) | Supports detoxification, replenishes levels of the antioxidant glutathione, improves respiratory health, and may reduce inflammation | May cause nausea, diarrhea, stomach pain, and in rare cases, allergic reactions (rash, difficulty breathing) |
Pterostilbene | Similar to resveratrol, supports cardiovascular health, acts as an antioxidant, may have anti-aging effects, and supports cognitive function | Generally safe; excessive intake may cause digestive discomfort or interact with blood pressure medications |
Vitamin C (Ascorbic Acid) | Boosts immune health, acts as an antioxidant, supports collagen production, and helps protect cells from oxidative damage | High doses can lead to stomach upset, diarrhea, and an increased risk of kidney stones |
Vitamin E | Acts as a potent antioxidant, supports skin health, enhances immune function, and protects cells from oxidative stress | High doses can cause nausea, stomach cramps, fatigue, and increased risk of bleeding, particularly in people on blood-thinning medications |
Protein Supplements
Names | Benefit | Side Effects |
---|---|---|
Whey Protein | Supports muscle growth and recovery, promotes weight loss by enhancing satiety, and provides all essential amino acids for overall health. | May cause digestive issues like bloating, gas, and stomach cramps, especially in those with lactose intolerance or dairy sensitivities |
Casein Protein | Slow-digesting protein that provides a sustained release of amino acids, supports muscle recovery, and may aid in reducing muscle breakdown during sleep. | Can cause digestive discomfort, such as bloating and constipation, particularly for individuals with dairy allergies or lactose intolerance. |
Plant-Based Proteins (Pea, Soy, Rice, Hemp) | Suitable for vegans and those with dairy sensitivities; provides essential amino acids, supports muscle growth, and may improve digestion due to fiber content. | Some individuals may experience bloating, gas, or stomach upset, especially when consuming soy-based proteins, which can also affect hormone levels if taken in excess |
Collagen Protein | Supports skin health, joint health, and muscle mass; may promote gut health and improve hair and nail strength. | Generally well-tolerated; high doses may lead to digestive issues such as bloating, heartburn, and a feeling of fullness |
Bone Broth Protein | Rich in collagen, supports joint and gut health, improves skin elasticity, and may aid in muscle recovery due to its amino acid content. | May cause digestive discomfort, such as bloating or gas, especially in those with sensitivities to certain ingredients found in bone broth |
Egg White Protein | Low in fat and carbohydrates, contains all essential amino acids, supports muscle growth, and is easily digestible | May cause allergic reactions in individuals sensitive to eggs; excessive intake can lead to digestive issues like bloating and gas |
Protein Bars | Convenient source of protein, supports muscle recovery, provides energy, and can be a healthy snack option when on-the-go. | Some protein bars contain added sugars, artificial sweeteners, and high fiber content, which can cause digestive issues such as bloating, gas, and stomach upset. |
Meal Replacement Shakes | Provides a balanced mix of protein, carbohydrates, fats, vitamins, and minerals; useful for weight management and convenient meal options. | May cause digestive issues, especially if they contain artificial sweeteners, high fiber content, or certain allergens (like soy or dairy). |
Weight Management Supplements
Names | Benefit | Side Effects |
---|---|---|
Green Coffee Bean Extract | Contains chlorogenic acid, which may help reduce the absorption of carbohydrates, regulate blood sugar levels, and support weight loss by increasing fat metabolism | May cause headaches, stomach upset, increased heart rate, anxiety, and insomnia due to its caffeine content |
Garcinia Cambogia | Contains hydroxycitric acid (HCA), which may suppress appetite, block fat production, and improve mood by increasing serotonin levels | Potential digestive issues such as nausea, stomach upset, headaches, and in rare cases, liver toxicity with excessive use |
Conjugated Linoleic Acid (CLA) | May help reduce body fat, support muscle retention, and improve metabolism, potentially aiding in weight management and body composition | Can cause digestive issues like stomach pain, nausea, and diarrhea; long-term use in high doses may increase the risk of fatty liver |
Raspberry Ketones | Believed to enhance fat metabolism by increasing adiponectin levels, which may support weight loss efforts when combined with a healthy diet and exercise. | Limited human studies; potential side effects include jitteriness, increased blood pressure, and rapid heartbeat, particularly for individuals sensitive to stimulants |
L-Carnitine | Supports the transportation of fatty acids into the mitochondria for energy production, which may aid in fat burning and improve exercise performance. | High doses can cause nausea, stomach cramps, diarrhea, and a "fishy" body odor. |
Caffeine | Boosts metabolism, enhances fat burning, increases energy levels, and may suppress appetite, making it a popular ingredient in many weight loss supplements | Can cause jitteriness, anxiety, insomnia, increased heart rate, and digestive issues, especially when consumed in high doses or by caffeine-sensitive individuals |
Apple Cider Vinegar | May help regulate blood sugar levels, reduce appetite, and support weight loss by promoting a feeling of fullness | High acidity can cause digestive discomfort, throat irritation, and potential erosion of tooth enamel if not properly diluted |
Hormonal and Sexual Health
Names | Benefit | Side Effects |
---|---|---|
Maca Root | May enhance libido, improve mood, support hormonal balance, and boost energy and endurance. Often used to alleviate symptoms of menopause and enhance fertility in both men and women. | Generally well-tolerated; in rare cases, may cause stomach upset, headache, or sleep disturbances |
Tribulus Terrestris | Commonly used to enhance libido, improve sexual performance, and support healthy testosterone levels, which may aid in muscle growth and physical endurance | High doses can cause digestive issues, such as stomach pain, cramping, and diarrhea. In some individuals, it may lead to sleep disturbances and restlessness |
DHEA (Dehydroepiandrosterone) | Supports hormone production, including testosterone and estrogen, which may improve libido, mood, energy, and bone density, and alleviate symptoms of aging | May cause acne, hair loss, changes in menstrual cycle, mood swings, and, in long-term use, can affect hormone levels and potentially increase the risk of hormone-related conditions |
Horny Goat Weed (Epimedium) | May enhance sexual function, improve libido, and alleviate symptoms of erectile dysfunction by increasing blood flow and supporting hormone balance | Possible side effects include dizziness, dry mouth, nausea, and increased heart rate, especially when consumed in high doses |
Fenugreek | May support healthy testosterone levels, improve libido, and enhance athletic performance. In women, it may help regulate blood sugar and alleviate symptoms of menopause | Can cause digestive issues such as diarrhea, gas, bloating, and a maple syrup-like odor in sweat and urine. High doses may interfere with blood clotting |
Ashwagandha | Supports stress reduction, may balance cortisol levels, improve mood, enhance libido, and support reproductive health in both men and women | Generally well-tolerated, but high doses may cause stomach upset, diarrhea, and drowsiness |
Zinc and Magnesium Aspartate (ZMA) | Supports hormone production, including testosterone, may improve muscle recovery, enhance sleep quality, and boost immune function. | Excessive zinc intake can cause nausea, diarrhea, and stomach cramps. High magnesium doses may lead to digestive issues, such as diarrhea |
Inositol (Myo-Inositol, D-Chiro-Inositol) | Supports ovarian function, promotes hormonal balance, and may improve fertility, especially in women with polycystic ovary syndrome (PCOS). Can also aid in regulating mood and reducing anxiety. | Generally well-tolerated; high doses may cause mild digestive issues, including nausea, gas, and diarrhea |
Evening Primrose Oil | Rich in gamma-linolenic acid (GLA), it may help regulate hormonal balance, reduce symptoms of PMS, menopause, and improve skin health | May cause mild digestive upset, headache, and nausea. In rare cases, can increase the risk of bleeding, especially when taken with blood-thinning medications |
Wild Yam Root | Often used to support hormone balance, may alleviate symptoms of menopause, PMS, and menstrual discomfort. Sometimes used in natural hormone replacement therapies | Generally safe; excessive intake can cause digestive upset, including nausea and vomiting |
Joint Health
Names | Benefit | Side Effects |
---|---|---|
Glucosamine | Supports the maintenance and repair of cartilage, reduces joint pain and stiffness, and may alleviate symptoms of osteoarthritis | May cause mild digestive issues, including nausea, heartburn, and diarrhea. Rarely, some people may experience allergic reactions, particularly if allergic to shellfish (a common source of glucosamine) |
Chondroitin | Helps maintain cartilage structure, reduces pain and inflammation in the joints, and may slow the progression of osteoarthritis | Generally well-tolerated; in some cases, it may cause mild digestive issues such as stomach pain, nausea, and diarrhea |
MSM (Methylsulfonylmethane) | Reduces joint pain and inflammation, supports healthy connective tissues, and may improve flexibility and mobility. | Generally safe, though high doses can cause digestive discomfort, including bloating, nausea, and diarrhea. Rarely, it may cause headaches or allergic reactions. |
Collagen | Supports joint health by aiding the repair of cartilage and connective tissues, may reduce joint pain, and improve mobility, particularly in cases of osteoarthritis | Generally well-tolerated; high doses may lead to digestive issues like bloating, heartburn, or a feeling of fullness |
Hyaluronic Acid | Helps lubricate and cushion joints, reducing pain and stiffness. Often used in the treatment of osteoarthritis and for joint hydration | Oral supplements are generally safe, but may cause mild digestive issues such as stomach discomfort. Injectable forms can occasionally cause temporary pain and swelling at the injection site. |
Boswellia (Boswellia Serrata) | Contains anti-inflammatory properties that may reduce joint pain, improve mobility, and alleviate symptoms of arthritis | May cause mild digestive issues, including nausea, stomach pain, and diarrhea. High doses can potentially affect liver function |
Turmeric/Curcumin | Reduces joint inflammation and pain due to its anti-inflammatory properties, may improve symptoms of arthritis and joint stiffness | High doses can cause digestive issues like nausea, stomach upset, and diarrhea. It may also interact with blood-thinning medications, increasing the risk of bleeding |
Omega-3 Fatty Acids (Fish Oil) | Reduces inflammation in the joints, alleviates symptoms of arthritis, and may support overall joint flexibility and mobility. | High doses can cause a fishy aftertaste, indigestion, nausea, diarrhea, and increased risk of bleeding, especially when taken with blood-thinning medications. |
SAMe (S-Adenosyl Methionine) | May help reduce joint pain, improve cartilage health, and alleviate symptoms of osteoarthritis. | Possible digestive issues, including nausea, gas, diarrhea, and, in some cases, anxiety or mood swings |
Sleep and Relaxation
Names | Benefit | Side Effects |
---|---|---|
Melatonin | Helps regulate the sleep-wake cycle, improves sleep quality, reduces symptoms of insomnia, and may help alleviate jet lag. | May cause drowsiness, dizziness, headaches, nausea, and, in some cases, vivid dreams or nightmares. Long-term use can affect natural melatonin production. |
Valerian Root | Promotes relaxation, reduces anxiety, and improves sleep quality by acting as a natural sedative. | Possible side effects include headaches, dizziness, stomach upset, and drowsiness. Long-term use may lead to dependency in some individuals. |
L-Theanine | Found in green tea, it promotes relaxation without sedation, reduces stress, and may improve sleep quality by increasing alpha brain waves. | Generally well-tolerated; excessive intake may cause headaches, dizziness, and mild gastrointestinal discomfort. |
5-HTP (5-Hydroxytryptophan) | Increases serotonin levels, which may improve mood, reduce anxiety, and promote better sleep. | Can cause nausea, stomach upset, drowsiness, and, in excessive amounts, may lead to serotonin syndrome, especially if taken with other medications that affect serotonin. |
GABA (Gamma-Aminobutyric Acid) | Acts as a neurotransmitter that promotes relaxation, reduces stress, and may improve sleep quality | Generally safe; high doses can cause drowsiness, dizziness, and, occasionally, tingling sensations in the face and neck |
Magnesium (Magnesium Glycinate, Magnesium Citrate) | Supports muscle relaxation, helps regulate neurotransmitters, and may improve sleep quality, especially in those with magnesium deficiency. | High doses can lead to digestive issues, including diarrhea, stomach cramps, and nausea. |
Passionflower | Reduces anxiety, promotes relaxation, and may improve sleep quality by increasing levels of gamma-aminobutyric acid (GABA) in the brain. | Possible side effects include dizziness, drowsiness, confusion, and stomach upset, particularly at high doses. |
Chamomile | Has mild sedative effects, promotes relaxation, reduces anxiety, and may improve sleep quality | Generally well-tolerated; possible allergic reactions in individuals sensitive to plants in the daisy family, and may cause mild stomach upset in some people. |
Magnolia Bark | Contains compounds that may help reduce anxiety, promote relaxation, and improve sleep by acting on GABA receptors. | May cause heartburn, dizziness, and headaches, particularly when consumed in high doses. |
Lavender | Used in aromatherapy or supplement form, it promotes relaxation, reduces anxiety, and may improve sleep quality. | Generally safe; oral consumption can cause constipation, headaches, and increased appetite in some cases. |
Digestive Health
Names | Benefit | Side Effect |
---|---|---|
Digestive Enzymes (e.g., Protease, Lipase, Amylase) | Aid in the breakdown of proteins, fats, and carbohydrates, improving digestion, reducing bloating, and alleviating symptoms of digestive disorders like irritable bowel syndrome (IBS). | May cause nausea, stomach cramps, diarrhea, or allergic reactions, especially in individuals sensitive to specific enzyme sources (e.g., those derived from pork or fungal origins) |
Probiotics (e.g., Lactobacillus, Bifidobacterium) | Restore and maintain a healthy gut flora balance, support digestion, boost immune health, alleviate symptoms of IBS, and may reduce occurrences of diarrhea. | Initially, may cause mild digestive discomfort, including gas, bloating, and diarrhea, as the body adjusts. Generally well-tolerated in the long term. |
Prebiotics (e.g., Inulin, Fructooligosaccharides - FOS) | Promote the growth of beneficial gut bacteria, support healthy digestion, enhance nutrient absorption, and may improve bowel regularity. | High doses can lead to gas, bloating, and stomach discomfort, particularly in individuals with sensitive digestive systems. |
Fiber Supplements (e.g., Psyllium Husk, Methylcellulose) | Improve bowel regularity, alleviate constipation, support gut health, and may help control blood sugar and cholesterol levels. | Can cause bloating, gas, and stomach cramps, especially when introduced suddenly or consumed in excessive amounts. Drinking plenty of water is recommended to prevent digestive blockages. |
Activated Charcoal | Binds to toxins and gases in the digestive tract, potentially reducing gas, bloating, and symptoms of indigestion | May cause constipation, black stools, and interfere with the absorption of medications or nutrients if taken too close to meals or other supplements. |
Betaine HCl | Increases stomach acid levels, aiding in protein digestion and nutrient absorption, and may help alleviate symptoms of acid reflux or heartburn caused by low stomach acid | High doses can cause stomach pain, irritation, and, if the stomach lining is compromised, may worsen ulcers or gastritis. |
Ginger | Supports digestion, reduces nausea, alleviates symptoms of indigestion, and may help reduce bloating and gas | High doses may cause heartburn, stomach upset, and increased risk of bleeding, particularly when taken with blood-thinning medications. |
Peppermint Oil | Relaxes the muscles in the gastrointestinal tract, reducing symptoms of IBS, bloating, and gas, and may help relieve indigestion | Can cause heartburn, allergic reactions, or skin irritation when used topically. Enteric-coated capsules are recommended to avoid stomach irritation. |
Aloe Vera | Supports digestion, may alleviate constipation, and soothes the lining of the gastrointestinal tract, potentially reducing symptoms of acid reflux | High doses can lead to diarrhea, electrolyte imbalances, and stomach cramps. Long-term use is not recommended without medical supervision. |
Slippery Elm | Forms a soothing gel-like substance in the stomach and intestines, which may help alleviate symptoms of acid reflux, IBS, and inflammatory bowel conditions. | Generally safe; however, it may interfere with the absorption of other medications if taken simultaneously. |
Energy and Performance Enhancers
Names | Benefit | Side effect |
---|---|---|
Caffeine | Boosts energy, enhances mental alertness, improves physical performance, and may aid in fat burning by increasing metabolism. | High doses can cause jitteriness, anxiety, insomnia, increased heart rate, digestive issues, and dependency. Excessive consumption may lead to headaches and dehydration. |
Creatine | Increases muscle strength, enhances high-intensity exercise performance, supports muscle recovery, and promotes muscle mass by aiding in the production of ATP (energy) | May cause water retention, bloating, digestive issues (such as stomach cramps), and muscle cramping. Long-term, excessive use could potentially strain the kidneys |
Beta-Alanine | Helps increase muscle carnosine levels, which can reduce muscle fatigue and enhance exercise performance, particularly in high-intensity and endurance activities | Can cause a harmless tingling sensation on the skin (paresthesia), especially at high doses. This effect usually diminishes with regular use |
L-Citrulline | Enhances blood flow, improves oxygen delivery to muscles, reduces muscle fatigue, and supports exercise performance. May help with muscle recovery by reducing soreness | Generally well-tolerated; high doses may lead to stomach discomfort, bloating, and diarrhea |
B Vitamins (e.g., B12, B6, B3) | Support energy metabolism by converting food into energy, reduce fatigue, improve mental clarity, and support the function of nerves and muscles. | Generally safe; however, excessive intake of certain B vitamins, particularly B3 (niacin), can cause flushing, nausea, and liver damage. High doses of B6 can cause nerve damage over time |
Branched-Chain Amino Acids (BCAAs) | Support muscle protein synthesis, reduce muscle soreness, improve exercise performance, and may help prevent muscle breakdown during intense exercise. | High doses can cause gastrointestinal discomfort, including nausea and bloating. Overuse may impact blood sugar regulation. |
L-Arginine | Converts to nitric oxide in the body, improving blood flow, enhancing exercise performance, and supporting muscle recovery. May also aid in reducing muscle fatigue. | High doses can lead to gastrointestinal issues, such as bloating, diarrhea, and stomach cramps. In some individuals, it may cause low blood pressure. |
L-Carnitine | Supports the transportation of fatty acids into mitochondria for energy production, which may enhance exercise performance, reduce muscle damage, and aid in fat burning. | High doses can cause nausea, stomach cramps, diarrhea, and a "fishy" body odor. |
Rhodiola Rosea | Acts as an adaptogen to reduce fatigue, improve mental performance, support endurance, and alleviate stress-related physical and mental fatigue | Possible side effects include dizziness, dry mouth, and sleep disturbances, particularly at high doses |
Nitric Oxide Boosters (e.g., L-Arginine, L-Citrulline) | Enhance blood flow, increase oxygen and nutrient delivery to muscles, improve exercise performance, and support muscle recovery | May cause stomach discomfort, bloating, and diarrhea, especially when consumed in high doses |
Green Tea Extract | Contains caffeine and catechins, which may boost energy, enhance fat burning, and improve physical performance. It also acts as an antioxidant. | High doses can cause stomach upset, constipation, and, due to its caffeine content, may cause jitteriness, insomnia, and increased heart rate. |
Immune Support
Names | Benefit | Side Effect |
---|---|---|
Vitamin C | Acts as a powerful antioxidant, supports the production and function of white blood cells, helps protect cells from oxidative damage, and may shorten the duration of colds. | High doses can cause digestive issues such as nausea, stomach cramps, and diarrhea. Excessive intake over time may increase the risk of kidney stones |
Vitamin D | Enhances pathogen-fighting effects of monocytes and macrophages, supports overall immune function, and may help reduce the risk of respiratory infections | Excessive intake can lead to elevated blood calcium levels, resulting in nausea, vomiting, poor appetite, constipation, and kidney damage. |
Zinc | Supports immune cell function, enhances the body's ability to fight infections, and may reduce the duration and severity of colds when taken at the onset of symptoms | High doses can cause nausea, vomiting, stomach cramps, diarrhea, and may interfere with copper absorption, potentially leading to deficiencies if used long-term |
Elderberry (Sambucus nigra) | Rich in antioxidants and vitamins, may help reduce the severity and duration of cold and flu symptoms, and supports overall immune health. | Raw or unripe elderberries can be toxic and cause nausea, vomiting, and diarrhea. Properly processed elderberry supplements are generally safe; however, excessive intake may still cause mild digestive issues |
Echinacea | May boost the immune system, reduce the severity of cold symptoms, and support the body's natural defenses against respiratory infections. | Can cause nausea, stomach pain, and allergic reactions, especially in individuals allergic to plants in the daisy family. Long-term use may lead to immune system suppression. |
Garlic | Has antimicrobial and antiviral properties, supports the immune system, and may help reduce the risk of colds and flu by boosting the body’s natural defenses. | May cause bad breath, body odor, digestive issues (such as stomach upset, bloating), and increased bleeding risk, especially if taken with blood-thinning medications |
Probiotics (e.g., Lactobacillus, Bifidobacterium) | Promote a healthy balance of gut bacteria, support the gut's immune response, and may help reduce the risk and duration of certain infections. | May cause mild digestive discomfort, including gas, bloating, and diarrhea, particularly when first starting supplementation. |
Astragalus | Acts as an adaptogen, supports immune health, enhances the body's resistance to stress, and may help ward off colds and upper respiratory infections. | Generally well-tolerated; high doses can cause digestive issues, including diarrhea, and in rare cases, allergic reactions such as rashes. |
Andrographis | Contains compounds that support immune health, may reduce the severity and duration of colds, and exhibit anti-inflammatory and antiviral properties. | Possible digestive discomfort, including nausea, diarrhea, and loss of appetite. In rare cases, may cause allergic reactions or changes in taste. |
N-Acetylcysteine (NAC) | Acts as a precursor to glutathione, an important antioxidant, supports respiratory health, and may help reduce the severity of respiratory infections. | May cause nausea, diarrhea, stomach pain, and, in rare cases, allergic reactions (rash, difficulty breathing) |
Bone and Teeth Health
Names | Benefits | Side Effects |
---|---|---|
Calcium | Essential for building and maintaining strong bones and teeth. Helps prevent osteoporosis and supports muscle function. | May cause constipation, bloating, or gas. Excessive intake can lead to kidney stones or calcification of soft tissues. |
Vitamin D | Promotes calcium absorption in the gut, supports bone growth and remodeling, and improves immune function | High doses may cause nausea, weakness, frequent urination, and hypercalcemia (too much calcium in the blood). |
Magnesium | Helps in calcium absorption, maintains bone density, and supports proper muscle and nerve function | Can cause diarrhea, nausea, and cramping at high doses. In rare cases, magnesium toxicity may occur, leading to low blood pressure or irregular heartbeat. |
Phosphorus | Works with calcium to build and maintain strong bones and teeth, helps filter out waste in the kidneys, and supports the body's use of energy. | Overuse may result in reduced calcium absorption, which can weaken bones and lead to kidney disease. |
Vitamin K2 | Directs calcium to bones and teeth, preventing calcium buildup in arteries (arterial calcification) and helping improve bone density | Rare, but excessive intake can interfere with blood-thinning medications like warfarin |
Collagen | Provides structural support to bones, teeth, and cartilage. May improve bone density and reduce joint pain | Generally well-tolerated, but some people may experience mild digestive issues such as bloating or heartburn |
Zinc | Supports bone formation and helps maintain healthy teeth. Plays a role in collagen synthesis and immune system support | High doses can cause nausea, vomiting, and interfere with copper absorption, potentially leading to a weakened immune system |
Boron | Aids in bone growth, improves calcium and magnesium absorption, and supports joint health | High doses may cause headaches, nausea, diarrhea, and in extreme cases, harm kidney function |
Strontium | May improve bone density and reduce the risk of fractures, especially in postmenopausal women with osteoporosis | Can cause nausea, diarrhea, and blood clotting issues. Long-term use may increase the risk of cardiovascular events |
Fluoride | Strengthens tooth enamel, reduces the risk of cavities, and supports bone mineralization | Excessive fluoride intake can lead to dental fluorosis (white spots on teeth) or skeletal fluorosis (joint stiffness and pain) |
Beauty and Skin Health
Names | Benefits | Side Effects |
---|---|---|
Collagen | Improves skin elasticity, reduces wrinkles, promotes hydration, and strengthens hair and nails. Supports overall skin structure | Generally well-tolerated, but may cause mild digestive issues like bloating or heartburn in some people |
Biotin (Vitamin B7) | Strengthens hair and nails, promotes healthy skin, and helps in the metabolism of fats and proteins crucial for cell health | Rare, but high doses may cause skin rashes, digestive upset, or interfere with laboratory test results |
Vitamin C | Powerful antioxidant that boosts collagen production, brightens skin, reduces wrinkles, and helps in wound healing. Protects against UV damage | High doses can cause digestive issues like diarrhea, nausea, and cramps |
Vitamin E | Antioxidant that protects skin from oxidative stress, promotes skin healing, and reduces inflammation. Hydrates and softens skin | High doses can lead to nausea, headache, fatigue, and bleeding problems in those taking blood thinners |
Omega-3 Fatty Acids | Hydrates the skin, reduces inflammation, promotes a smoother complexion, and may help with conditions like eczema and psoriasis | Fishy aftertaste, indigestion, and in high doses, it can increase the risk of bleeding or interact with blood-thinning medications |
Zinc | Helps with acne control, reduces inflammation, supports wound healing, and protects skin from UV damage | High doses can cause nausea, vomiting, loss of appetite, and interfere with copper absorption |
Hyaluronic Acid | Improves skin hydration, reduces the appearance of fine lines and wrinkles, and supports skin elasticity and firmness | Rare in supplement form, but excessive use may cause skin irritation or allergic reactions when applied topically |
Silica | Promotes collagen production, strengthens hair, nails, and skin, and helps maintain skin elasticity and hydration | Excessive intake can cause kidney issues or digestive problems, though side effects are rare at normal doses |
Evening Primrose Oil | Rich in gamma-linolenic acid (GLA), it helps moisturize dry skin, reduces inflammation, and may ease symptoms of eczema and acne | May cause nausea, headache, or stomach upset in some individuals |
Coenzyme Q10 (CoQ10) | Powerful antioxidant that promotes skin regeneration, reduces signs of aging, and protects skin cells from damage caused by UV exposure | Mild side effects may include digestive upset, nausea, or loss of appetite |
Lycopene | Protects skin from sun damage, reduces inflammation, and promotes an even skin tone by preventing oxidative stress | High doses may lead to skin discoloration (orange tint) or digestive issues |
Astaxanthin | A potent antioxidant that reduces wrinkles, improves skin elasticity, and protects skin from UV-induced damage | Generally safe, but some people may experience digestive upset or reddish skin tint at very high doses |
Probiotics | Promotes gut health, which can improve skin conditions like acne, eczema, and rosacea. Helps balance skin microbiome and reduce inflammation | Can cause mild digestive issues such as gas, bloating, or stomach upset in some individuals |
Resveratrol | An antioxidant that fights aging, reduces redness, and improves skin elasticity. Protects against environmental stressors | High doses may cause digestive upset, headache, or interact with blood-thinning medications |
Vitamin A (Retinol) | Promotes cell turnover, reduces fine lines and wrinkles, and improves skin texture and tone. Effective for treating acne | High doses can lead to dry skin, peeling, irritation, and liver toxicity if consumed excessively |
Alpha-Lipoic Acid (ALA) | Reduces inflammation, protects the skin from oxidative stress, and improves skin texture by boosting collagen | May cause nausea, rash, or low blood sugar in some people |
Ceramides | Help retain skin moisture, reduce dryness, and strengthen the skin barrier, making skin look plump and hydrated | Generally well-tolerated, but high doses may cause mild digestive discomfort |
Nootropics (Cognitive Enhancers)
Names | Benefit | Side Effect |
---|---|---|
Caffeine | Increases alertness, improves focus, enhances short-term memory, and boosts energy levels | Can cause jitteriness, anxiety, restlessness, insomnia, and dependency at high doses. May lead to digestive upset or increased heart rate |
L-Theanine | Promotes relaxation without drowsiness, enhances focus and attention, and improves cognitive performance when paired with caffeine | Generally well-tolerated, but may cause mild headaches or dizziness in some individuals. |
Bacopa Monnieri | Improves memory, enhances cognitive function, and reduces anxiety and stress. May also protect brain cells from oxidative stress | Can cause digestive issues like nausea, bloating, and diarrhea, especially at high doses. May also cause dry mouth or fatigue |
Ginkgo Biloba | Improves blood flow to the brain, enhances memory, boosts cognitive function, and may help with age-related cognitive decline | Can cause headaches, dizziness, digestive upset, or allergic skin reactions. May increase bleeding risk, especially when combined with blood thinners |
Rhodiola Rosea | Reduces fatigue, improves mental clarity, enhances memory and focus, and helps manage stress | May cause dizziness, dry mouth, or difficulty sleeping. In rare cases, it may lead to irritability or nervousness. |
Creatine | Enhances short-term memory and intelligence in stressful situations, boosts energy in brain cells, and supports cognitive function | Generally safe, but some may experience bloating, weight gain, or digestive discomfort. High doses may strain kidney function in individuals with preexisting conditions |
Phosphatidylserine | Supports memory, cognitive function, and mental clarity. May help slow age-related cognitive decline and improve focus | Generally well-tolerated, but some may experience insomnia or digestive upset at high doses |
Lion’s Mane Mushroom | Stimulates nerve growth factor (NGF), improves memory and cognitive function, and may protect against age-related brain decline | Rare, but some may experience skin rashes, digestive upset, or difficulty breathing (in allergic individuals) |
Alpha-GPC (AlphaGlycerylphosphorylcholine) | Boosts memory and learning, enhances focus and mental clarity, and increases acetylcholine levels (a key neurotransmitter for learning) | May cause headaches, dizziness, or digestive upset. Some people report experiencing fatigue or nervousness at higher doses |
Choline | Supports brain health by producing acetylcholine, improves memory and learning, and enhances cognitive function | High doses can lead to fishy body odor, sweating, digestive upset, or low blood pressure |
Piracetam | Enhances cognitive function, improves memory, and boosts focus. Often used for age-related cognitive decline | May cause insomnia, nervousness, headaches, or digestive upset. Long-term use may result in tolerance, reducing its effectiveness |
Noopept | Improves memory, learning, and cognitive performance. Also offers neuroprotective benefits by enhancing brain health | Common side effects include headaches, irritability, nausea, and sleep disturbances. Some users may experience mood swings or brain fog |
Ashwagandha | Reduces stress and anxiety, enhances cognitive function, improves memory, and supports mental clarity | May cause digestive upset, headaches, or drowsiness. In high doses, it could lead to low blood pressure or thyroid imbalances |
Acetyl-L-Carnitine (ALCAR) | Enhances focus and cognitive performance, supports memory, and increases mental energy by boosting mitochondrial function. | High doses may cause restlessness, insomnia, or digestive issues like nausea and heartburn. Rarely, it may increase anxiety in some individuals |
N-Acetyl Cysteine (NAC) | Boosts brain health, improves focus, reduces symptoms of mental fatigue, and has neuroprotective properties | Can cause digestive discomfort, nausea, vomiting, or headaches. High doses may lead to low blood pressure or kidney issues |
Huperzine A | Enhances memory, increases focus, and protects against cognitive decline by inhibiting the breakdown of acetylcholine | May cause digestive issues, headaches, dizziness, or insomnia. Long-term use can lead to buildup, so cycling off is recommended |
Panax Ginseng | Improves focus, reduces mental fatigue, enhances memory, and supports cognitive function under stress | May cause headaches, digestive upset, or nervousness. Long-term use or high doses can lead to in |
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